Fingolimod modulates microglial activation to augment markers of remyelination
Baker David; Giovannoni Gavin; Jackson Samuel J · 2011 · Journal of Neuroinflammation
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Abstract
Abstract Introduction Microglial activation in multiple sclerosis has been postulated to contribute to long-term neurodegeneration during disease. Fingolimod has been shown to impact on the relapsing remitting phase of disease by modulating autoreactive T-cell egress from lymph organs. In addition, it is brain penetrant and has been shown to exert multiple effects on nervous system cells. Methods In this study, the impact of fingolimod and other sphingosine-1-phosphate receptor active molecules following lysophosphotidyl choline-induced demyelination was examined in the rat telencephalon reagg
Abstract by Baker David; Giovannoni Gavin; Jackson Samuel J, Journal of Neuroinflammation (2011) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/1742-2094-8-76