SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor
Mohamad Wessam Alnouri; Kenneth Anthony Roquid; Rémy Bonnavion; Haaglim Cho; Jan Heering; Jeonghyeon Kwon; Yannick Jäger; Shengpeng Wang · 2024 · Proceedings of the National Academy of Sciences
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Abstract
Inflammation is a protective response to pathogens and injury. To be effective it needs to be resolved by endogenous mechanisms in order to avoid prolonged and excessive inflammation, which can become chronic. Specialized pro-resolving mediators (SPMs) are a group of lipids derived from omega-3 fatty acids, which can induce the resolution of inflammation. How SPMs exert their anti-inflammatory and pro-resolving effects is, however, not clear. Here, we show that SPMs such as protectins, maresins, and D-series resolvins function as biased positive allosteric modulators (PAM) of the prostaglandin
Abstract by Mohamad Wessam Alnouri; Kenneth Anthony Roquid; Rémy Bonnavion; Haaglim Cho; Jan Heering; Jeonghyeon Kwon; Yannick Jäger; Shengpeng Wang, Proceedings of the National Academy of Sciences (2024) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1073/pnas.2407130121