Association study of the vesicular monoamine transporter 1 (VMAT1) gene with schizophrenia in a Japanese population
Arima Kunimasa; Hori Hiroaki; Shizuno Tomoko; Kondo Hitomi; Iijima Yoshimi; Richards Misty; Saitoh Osamu; Kunugi Hiroshi · 2006 · Behavioral and Brain Functions
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Vesicular monoamine transporters (VMATs) mediate accumulation of monoamines such as serotonin, dopamine, adrenaline, and noradrenaline from the cytoplasm into storage organelles. The VMAT1 (alternatively solute carrier family 18: SLC18A1) regulates such biogenic amines in neuroendocrine systems. The VMAT1 gene maps to chromosome 8p21.3, a locus with strong evidence of linkage with schizophrenia. A recent study reported that a non-synonymous single nucleotide polymorphism (SNP) of the gene (Pro4Thr) was associated with schizophrenia. Methods We attempted to replicate this fi
Abstract by Arima Kunimasa; Hori Hiroaki; Shizuno Tomoko; Kondo Hitomi; Iijima Yoshimi; Richards Misty; Saitoh Osamu; Kunugi Hiroshi, Behavioral and Brain Functions (2006) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/1744-9081-2-39