Synthesis of 6-Halo-Substituted Pericosine A and an Evaluation of Their Antitumor and Antiglycosidase Activities
Yoshihide Usami; Yoshino Mizobuchi; Mai Ijuin; Takeshi Yamada; Mizuki Morita; Koji Mizuki; Hiroki Yoneyama; Shinya Harusawa · 2022 · Marine Drugs
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The enantiomers of 6-fluoro-, 6-bromo-, and 6-iodopericosine A were synthesized. An efficient synthesis of both enantiomers of pericoxide via 6-bromopericosine A was also developed. These 6-halo-substituted pericosine A derivatives were evaluated in terms of their antitumor activity against three types of tumor cells (p388, L1210, and HL-60) and glycosidase inhibitory activity. The bromo- and iodo-congeners exhibited moderate antitumor activity similar to pericosine A against the three types of tumor cell lines studied. The fluorinated compound was less active than the others, including perico
Abstract by Yoshihide Usami; Yoshino Mizobuchi; Mai Ijuin; Takeshi Yamada; Mizuki Morita; Koji Mizuki; Hiroki Yoneyama; Shinya Harusawa, Marine Drugs (2022) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3390/md20070438