Phase II study of rucaparib and nivolumab in patients with leiomyosarcoma
Robert G Maki; Martina Bradic; Phillip Wong; William Tap; Vicky Makker; Sandra D’Angelo; Angela Green; Mrinal M Gounder · 2025 · Journal for ImmunoTherapy of Cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background Objective responses to immune checkpoint inhibitors (ICI) in leiomyosarcoma (LMS) are rare. Response rates may be increased by combination with other drugs known to promote immune infiltration, such as poly(ADP-ribose) polymerase (PARP) inhibitors, which have led to benefit in BRCA-altered uterine LMS. We therefore evaluated the combination of a PARP inhibitor, rucaparib, and the anti-programmed death receptor-1 monoclonal antibody, nivolumab, in patients with advanced LMS and investigated its effects on the tumor immune microenvironment.Methods This was an open-label, single-center
Abstract by Robert G Maki; Martina Bradic; Phillip Wong; William Tap; Vicky Makker; Sandra D’Angelo; Angela Green; Mrinal M Gounder, Journal for ImmunoTherapy of Cancer (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1136/jitc-2025-012020