Impact of innate lymphoid cell type 2 in chronic lymphocytic leukemia on the function of treg and CD8+ T cells through IL-9
Ruixue Yang; Xuejiao Zeng; Xierenguli Alimu; Jianhua Qu · 2025 · Cancer Immunology, Immunotherapy
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Abstract
Abstract Objective This study investigated the impact of innate lymphoid cell type 2 (ILC2s) on the function of regulatory T cells (Treg) and CD8+ T cells in chronic lymphocytic leukemia (CLL) through IL-9. Methods Peripheral blood samples were collected from CLL patients (n = 52) and healthy controls (n = 30). ILC2 proportions and IL-9 levels were assessed using flow cytometry and ELISA. Immunofluorescence staining was performed to stain GATA3, CRTH2, and IL-9 in cervical lymph nodes from CLL patients (n = 10) and control subjects with reactive lymphadenitis (n = 10). Correlation analysis bet
Abstract by Ruixue Yang; Xuejiao Zeng; Xierenguli Alimu; Jianhua Qu, Cancer Immunology, Immunotherapy (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1007/s00262-025-04082-4