Fluorescence-based mapping of condensate dielectric permittivity uncovers hydrophobicity-driven membrane interactions
Elias Sabri; Agustín Mangiarotti; Rumiana Dimova · 2026 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Biomolecular condensates, essential for cellular organization, possess mesoscale properties largely governed by hydrophobicity, influencing molecule partitioning and material characteristics like viscosity, surface tension, and hydration. While hydrophobicity's role is increasingly recognized, its impact on membrane-condensate interactions remains unexplored. Here, we combine hyperspectral imaging of an environment-sensitive dye and phasor analysis, to quantitatively map the local dielectric permittivity of both condensates and their environment with pixel resolution. This robust method senses
Abstract by Elias Sabri; Agustín Mangiarotti; Rumiana Dimova, Nature Communications (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41467-026-71273-7