A Francisella tularensis Live Vaccine Strain That Improves Stimulation of Antigen-Presenting Cells Does Not Enhance Vaccine Efficacy
Deanna Schmitt; Dawn M. O’Dee; Joseph Horzempa; Paul E. Carlson; Brian C. Russo; Jacqueline M. Bales; Matthew J. Brown; Gerard J. Nau · 2012 · PLoS ONE
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Abstract
Vaccination is a proven strategy to mitigate morbidity and mortality of infectious diseases. The methodology of identifying and testing new vaccine candidates could be improved with rational design and in vitro testing prior to animal experimentation. The tularemia vaccine, Francisella tularensis live vaccine strain (LVS), does not elicit complete protection against lethal challenge with a virulent type A Francisella strain. One factor that may contribute to this poor performance is limited stimulation of antigen-presenting cells. In this study, we examined whether the interaction of genetical
Abstract by Deanna Schmitt; Dawn M. O’Dee; Joseph Horzempa; Paul E. Carlson; Brian C. Russo; Jacqueline M. Bales; Matthew J. Brown; Gerard J. Nau, PLoS ONE (2012) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pone.0031172