Biomechanical control of vascular morphogenesis by the surrounding stiffness
Yasuyuki Hanada; Semanti Halder; Yuichiro Arima; Misato Haruta; Honami Ogoh; Shuntaro Ogura; Yukihiko Shiraki; Sota Nakano · 2025 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Sprouting angiogenesis is a form of morphogenesis which expands vascular networks from the preexisting ones in both developmental and postnatal settings. During this process, endothelial cells (ECs) collectively elongate new branches via their directional movement. Almost simultaneously, the vessel lumen develops internally with blood flowing into it. Our recent study has suggested lumen expansion induced by blood inflow to be an inhibitory factor for branch elongation. However, the precise mechanism governing efficient angiogenic branch elongation during lumen development under the i
Abstract by Yasuyuki Hanada; Semanti Halder; Yuichiro Arima; Misato Haruta; Honami Ogoh; Shuntaro Ogura; Yukihiko Shiraki; Sota Nakano, Nature Communications (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41467-025-61804-z