Pharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design
Marja-Liisa Nuotio; Heini Sánez Tähtisalo; Alexandra Lahtinen; Kati Donner; F Fyhrquist; Markus Perola; Kimmo Kontula; Timo P. Hiltunen · 2022 · Epigenetics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Essential hypertension remains the leading risk factor of global disease burden, but its treatment goals are often not met. We investigated whether DNA methylation is associated with antihypertensive responses to a diuretic, a beta-blocker, a calcium channel blocker or an angiotensin receptor antagonist. In addition, since we previously showed an SNP at the transcription start site (TSS) of the catecholamine biosynthesis-related ACY3 gene to associate with blood pressure (BP) response to beta-blockers, we specifically analysed the association of methylation sites close to the ACY3 TSS with BP
Abstract by Marja-Liisa Nuotio; Heini Sánez Tähtisalo; Alexandra Lahtinen; Kati Donner; F Fyhrquist; Markus Perola; Kimmo Kontula; Timo P. Hiltunen, Epigenetics (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1080/15592294.2022.2038418