Genome‐wide analysis of adolescent psychotic‐like experiences shows genetic overlap with psychiatric disorders
Oliver Pain; Frank Dudbridge; Alastair G. Cardno; Daniel Freeman; Yi Lu; Sebastian Lundström; Paul Lichtenstein; Angelica Ronald · 2018 · American Journal of Medical Genetics Part B Neuropsychiatric Genetics
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Abstract
This study aimed to test for overlap in genetic influences between psychotic-like experience traits shown by adolescents in the community, and clinically-recognized psychiatric disorders in adulthood, specifically schizophrenia, bipolar disorder, and major depression. The full spectra of psychotic-like experience domains, both in terms of their severity and type (positive, cognitive, and negative), were assessed using self- and parent-ratings in three European community samples aged 15-19 years (Final N incl. siblings = 6,297-10,098). A mega-genome-wide association study (mega-GWAS) for each p
Abstract by Oliver Pain; Frank Dudbridge; Alastair G. Cardno; Daniel Freeman; Yi Lu; Sebastian Lundström; Paul Lichtenstein; Angelica Ronald, American Journal of Medical Genetics Part B Neuropsychiatric Genetics (2018) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1002/ajmg.b.32630