Melanoma: Pathogenesis and Targeted Therapy
Yang Fu; Jie Liu; Zeming Mo; Bin Wang; Yaotiao Deng; Y. Jiang · 2026 · MedComm
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
ABSTRACT Melanoma is the most aggressive skin malignant tumor, typically exhibiting a high mutation burden and potentially harboring mutations in NRAS, BRAF, or NF1. To enhance survival rates, these driver alterations can achieve significant antitumor activity through targeted therapy. In the past decade, BRAF inhibitors combined with MEK inhibitors significantly improved the prognosis of BRAF mutation melanoma. Nevertheless, researchers have attempted various strategies to block the NRAS signaling pathway, NRAS mutation in melanoma is still considered to be untargetable. In recent years, MEK
Abstract by Yang Fu; Jie Liu; Zeming Mo; Bin Wang; Yaotiao Deng; Y. Jiang, MedComm (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1002/mco2.70566