A randomized phase II/III study of paclitaxel/carboplatin/metformin versus paclitaxel/carboplatin/placebo as initial therapy for measurable stage III or IVA, stage IVB, or recurrent endometrial cancer: An NRG oncology/GOG study
Victoria Bae‐Jump; Michael W. Sill; Paola A. Gehrig; Jason D. Merker; David L. Corcoran; Adam D. Pfefferle; Michele C. Hayward; Joan L. Walker · 2025 · Gynecologic Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
INTRODUCTION: We evaluated the efficacy of the addition of the anti-diabetic drug metformin to standard-of-care paclitaxel and carboplatin (PC) in patients with advanced and recurrent endometrial cancer (EC). METHODS: In this phase II/III…
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Metadata source: OpenAlex · DOI 10.1016/j.ygyno.2025.03.003