A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform
Karsten Suhre; Qingwen Chen; Anna Halama; Kevin Mendez; Amber Dahlin; Nisha Stephan; Gaurav Thareja; Hina Sarwath · 2025 · Nature Genetics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
Most studies to date of protein quantitative trait loci (pQTLs) have relied on affinity proteomics platforms, which provide only limited information about the targeted protein isoforms and may be affected by genetic variation in their epitope binding. Here we show that mass spectrometry (MS)-based proteomics can complement these studies and provide insights into the role of specific protein isoform and epitope-altering variants. Using the Seer Proteograph nanoparticle enrichment MS platform, we identified and replicated new pQTLs in a genome-wide association study of proteins in blood plasma s
Abstract by Karsten Suhre; Qingwen Chen; Anna Halama; Kevin Mendez; Amber Dahlin; Nisha Stephan; Gaurav Thareja; Hina Sarwath, Nature Genetics (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41588-025-02413-w