DCDB 2.0: a major update of the drug combination database
Yu Liu; Qichun Wei; Guocan Yu; Wei Gai; Yixue Li; Xudong Chen · 2014 · Database
WASTE classifies this as Null Dataset · AI classification, approximate
A negative-result dataset — reusable evidence that an expected effect wasn't there.
Abstract
Experience in clinical practice and research in systems pharmacology suggested the limitations of the current one-drug-one-target paradigm in new drug discovery. Single-target drugs may not always produce desired physiological effects on the entire biological system, even if they have successfully regulated the activities of their designated targets. On the other hand, multicomponent therapy, in which two or more agents simultaneously interact with multiple targets, has attracted growing attention. Many drug combinations consisting of multiple agents have already entered clinical practice, esp
Abstract by Yu Liu; Qichun Wei; Guocan Yu; Wei Gai; Yixue Li; Xudong Chen, Database (2014) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1093/database/bau124