The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments
John P. Veluchamy; John P. Veluchamy; Nina Kok; Hans J. van der Vliet; Henk M. W. Verheul; Tanja D. de Gruijl; Jan Spanholtz · 2017 · Frontiers in Immunology
WASTE classifies this as Abandoned Hypothesis · AI classification, approximate
A hypothesis was tested and not supported — a dead end worth knowing about before you pursue it.
The finding, in one line
“Early studies from autologous NK cells have failed to demonstrate significant clinical benefit.”
Abstract
Natural killer (NK) cells are critical immune effector cells in the fight against cancer. As NK cells in cancer patients are highly dysfunctional and reduced in number, adoptive transfer of large numbers of cytolytic NK cells and their potential to induce relevant antitumor responses are widely explored in cancer immunotherapy. Early studies from autologous NK cells have failed to demonstrate significant clinical benefit. In this review, the clinical benefits of adoptively transferred allogeneic NK cells in a transplant and non-transplant setting are compared and discussed in the context of re
Abstract by John P. Veluchamy; John P. Veluchamy; Nina Kok; Hans J. van der Vliet; Henk M. W. Verheul; Tanja D. de Gruijl; Jan Spanholtz, Frontiers in Immunology (2017) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fimmu.2017.00631