A novel HIV-1 restriction factor that is biologically distinct from APOBEC3 cytidine deaminases in a human T cell line CEM.NKR
Zhou Tao; Han Yanxing; Dang Ying; Wang Xiaojun; Zheng Yong-Hui · 2009 · Retrovirology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
Abstract Background Isolation of novel retroviral restriction factors will open new avenues for anti-HIV/AIDS treatment. Although HIV-1 replication is restricted by APOBEC3G/APOBEC3F, TRIM5α, and CD317, none defend HIV-1 infection under natural conditions. Previously, we demonstrated a host factor from the human T cell line CEM.NKR that potently restricted wild-type HIV-1 replication. Interestingly, this restriction resembled the APOBEC3G/APOBEC3F pattern in that viral replication was inhibited from the second round of replication cycle at a post-entry step. Results Here, we further characteri
Abstract by Zhou Tao; Han Yanxing; Dang Ying; Wang Xiaojun; Zheng Yong-Hui, Retrovirology (2009) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/1742-4690-6-31