Synthesis and multilevel evaluation of benzimidazole-based anticancer compounds: DNA/serum albumin interaction, and in-depth theoretical insights
Sevgi Kundu; Senem Akkoç; Yalçın Erzurumlu; Sadeq K. Alhag; Lamya Ahmed Alkeridis; Mehran Feizi‐Dehnayebi · 2026 · Molecular and Cellular Biochemistry
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Within the scope of this investigation, two novel compounds ( 3a and 3b ) were designed and synthesized in two steps. Compounds 3a and 3b were tested utilizing the MTT study to evaluate their in vitro cytotoxic activity against healthy human embryonic kidney, lung cancer, breast cancer, and human liver cancer cell lines. It was determined that compound 3b exhibited high levels of cytotoxic activity against both liver and breast cancer cell lines, with IC 50 values of 10.83 and 11.55 µM, respectively. Also, to elucidate the anticancer mechanism of compounds, pro-apoptotic BAX and BiD ,
Abstract by Sevgi Kundu; Senem Akkoç; Yalçın Erzurumlu; Sadeq K. Alhag; Lamya Ahmed Alkeridis; Mehran Feizi‐Dehnayebi, Molecular and Cellular Biochemistry (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1007/s11010-026-05600-3