Somatic epimutations cap genetic determinism in the human diploid chromatin epigenome
Mitchell Robert Vollger; Elliott G. Swanson; Shane J. Neph; Benjamin J. Mallory; Danilo Dubocanin; Ching‐Huang Ho; Yong-Han Hank Cheng; Jane Ranchalis · 2026 · Cell
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Abstract
Diploid human cells contain two non-identical genomes, and differences in their regulation underlie human development and disease. We present Fiber-seq Inferred Regulatory Elements (FIRE) and show that FIRE provides a more comprehensive and quantitative snapshot of the accessible chromatin landscape across the 6 Gbp diploid human genome, overcoming previously known and unknown biases afflicting our existing regulatory element catalog. FIRE provides a comprehensive genome-wide map of haplotype-selective chromatin accessibility (HSCA), exposing novel imprinted elements that lack underlying paren
Abstract by Mitchell Robert Vollger; Elliott G. Swanson; Shane J. Neph; Benjamin J. Mallory; Danilo Dubocanin; Ching‐Huang Ho; Yong-Han Hank Cheng; Jane Ranchalis, Cell (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.cell.2026.09.034