Significant differences in terms of codon usage bias between bacteriophage early and late genes: a comparative genomics analysis
Oriah Mioduser; Eli Goz; Tamir Tuller · 2017 · BMC Genomics
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The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Viruses undergo extensive evolutionary selection for efficient replication which effects, among others, their codon distribution. In the current study, we aimed at understanding the way evolution shapes the codon distribution in early vs. late viral genes in terms of their expression during different stages in the viral replication cycle. To this end we analyzed 14 bacteriophages and 11 human viruses with available information about the expression phases of their genes. RESULTS: We demonstrated evidence of selection for distinct composition of synonymous codons in early and late vi
Abstract by Oriah Mioduser; Eli Goz; Tamir Tuller, BMC Genomics (2017) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s12864-017-4248-7