Gut microbial metabolites in inflammatory bowel disease: immunological mechanisms regulating Treg/Th17 balance and therapeutic potential
He Chen; Shaochen Yu; Mengjie Zhang; Beibei Tian; Langlang Yang; Jian Lu · 2026 · Frontiers in Immunology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder resulting from a combination of genetic susceptibility, environmental factors, and an abnormal immune response of the intestinal immune system to commensal microorganisms. The gut microbiota and its metabolites play a pivotal role in maintaining intestinal immune homeostasis. Recent advances indicate that dysbiosis of the microbiota is accompanied by alterations in its metabolic functions. Abnormal levels of key metabolites, particularly short-chain fatty acids (SCFAs), tryptophan derivatives, and secondary bile acids, are clo
Abstract by He Chen; Shaochen Yu; Mengjie Zhang; Beibei Tian; Langlang Yang; Jian Lu, Frontiers in Immunology (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fimmu.2026.1780865