TAK1 operates at the primary cilium in non-canonical TGFB/BMP signaling to control heart development
Canan Doğanlı; Oskar Kaaber Thomsen; Daniel A. Baird; Yeasmeen Ali; Menachem Viktor Sarusie; Enrique Audain; Line Jeanett Jessen; Pauline Munck Truelsen · 2026 · PLoS Biology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Pathogenic variants in the genes encoding the non-canonical TGFB signaling components TAK1 (MAP3K7 ) , TAB2 and PKA-Cα (PRKACA) cause rare multisystem disorders, which may include congenital heart disease (CHD). To investigate the role of TAK1 signaling in CHD, we performed genetic analysis of CHD patients and discovered an increased burden of rare TAB2 and TAK1 variants in patients with extracardiac abnormalities. To address the mechanism of TAK1 in heart development, we performed experiments in cell and animal models. Zebrafish tak1 and tab2 mutants presented with cardiac and extracardiac de
Abstract by Canan Doğanlı; Oskar Kaaber Thomsen; Daniel A. Baird; Yeasmeen Ali; Menachem Viktor Sarusie; Enrique Audain; Line Jeanett Jessen; Pauline Munck Truelsen, PLoS Biology (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pbio.3003902