Gut microbiome and its metabolites in liver cirrhosis: mechanisms and clinical implications
Luyuan Chang; Yang Liu; Haipeng Li; Jiaqi Yan; Wei Wu; Nuo Chen; Chunyu Ma; Xinyi Zhao · 2025 · Frontiers in Cellular and Infection Microbiology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Cirrhosis remains a significant global health burden, causing approximately 1.4-1.5 million deaths each year and contributing to nearly 46 million disability-adjusted life years (DALYs) worldwide. Increasing evidence identifies the gut-liver axis as a central driver of disease progression, wherein intestinal dysbiosis, barrier disruption, and microbe-derived metabolites collectively exacerbate inflammation, fibrogenesis, and related complications. Across more than 40 recent studies, gut microbial α-diversity declined by 30-60%, and over 80% reported a marked depletion of short-chain fatty acid
Abstract by Luyuan Chang; Yang Liu; Haipeng Li; Jiaqi Yan; Wei Wu; Nuo Chen; Chunyu Ma; Xinyi Zhao, Frontiers in Cellular and Infection Microbiology (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fcimb.2025.1717696