Cecropin A Alleviates Inflammation Through Modulating the Gut Microbiota of C57BL/6 Mice With DSS-Induced IBD
Zhenya Zhai; Fan Zhang; Ruihua Cao; Xiaojun Ni; Zhongquan Xin; Jinping Deng; Guoyao Wu; Wenkai Ren · 2019 · Frontiers in Microbiology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The present study is undertaken to assess the alleviating effects of antimicrobial peptide cecropin A on inflammatory bowel disease (IBD) in C57BL/6 mice and changes in the gut microbiota, compared to an antibiotic gentamicin. Different doses of cecropin A were intraperitoneally injected into C57BL/6 mice for 5 days to determine the safe doses. The injection doses at ≤ 15 mg/kg showed no negative impact on the liver, heart, spleen and kidney. The severe and moderate IBD mice model was successfully established via supplementation of 4% or 2.5% dextran sulfate sodium (DSS) in drinking water for
Abstract by Zhenya Zhai; Fan Zhang; Ruihua Cao; Xiaojun Ni; Zhongquan Xin; Jinping Deng; Guoyao Wu; Wenkai Ren, Frontiers in Microbiology (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fmicb.2019.01595