Polygenic risk scores in schizophrenia with clinically significant copy number variants
Satoru Taniguchi; Kohei Ninomiya; Itaru Kushima; Takeo Saito; Ayu Shimasaki; Takaya Sakusabe; Yukihide Momozawa; Michiaki Kubo · 2019 · Psychiatry and Clinical Neurosciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
AIMS: Recent studies have revealed that the interplay between polygenic risk scores (PRS) and large copy number variants (CNV; >500kb) is essential for the etiology of schizophrenia (SCZ). To replicate previous findings, including those for smaller CNV (>10kb), the PRS between SCZ patients with and without CNV were compared. METHODS: The PRS were calculated for 724 patients with SCZ and 1178 healthy controls (HC), genotyped using array-based comparative genomic hybridization and single nucleotide polymorphisms chips, and comparisons were made between cases and HC, or between subjects with and
Abstract by Satoru Taniguchi; Kohei Ninomiya; Itaru Kushima; Takeo Saito; Ayu Shimasaki; Takaya Sakusabe; Yukihide Momozawa; Michiaki Kubo, Psychiatry and Clinical Neurosciences (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1111/pcn.12926