Targeted Hyaluronan Degradation Enhanced Tumor Growth Inhibition in Gastrointestinal Cancer Models
Fulai Zhou; Guangmao Mu; Honglei Bi; Limin Chen; Zhengxia Zha; Ying Jin; Mark L. Chiu · 2025 · Cancers
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background. The dense hyaluronan (HA)-rich stroma in solid tumors can prevent effective tumor growth inhibition by hindering drug delivery and immune cell infiltration. However, the degradation of HA alone by systemic delivery of hyaluronidase has not shown significant improvement of tumor growth inhibition. Objectives/Methods. In this study, we targeted hyaluronan degradation by using antibody–enzyme (AbEn) molecules by fusing antibodies to a recombinant human hyaluronidase (HYAL). Results. The AbEn molecules were stable, retained both antigen-binding and enzymatic activities, and demonstrate
Abstract by Fulai Zhou; Guangmao Mu; Honglei Bi; Limin Chen; Zhengxia Zha; Ying Jin; Mark L. Chiu, Cancers (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/cancers17213411