Lack of Changes in Soluble Interleukin-2 Receptor Serum Levels during Chemotherapy-induced Lymphocyte Damage
C. Archili; P. Lissoni; G. Cattaneo; F. Rovelli; F. Brivio; G. Tancini; S. Barni · 1990 · The International Journal of Biological Markers
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Abstract
The biological significance of soluble IL-2 receptors (sIL-2R) is still unknown; in particular, it is not yet clear whether their increase in the blood may reflect activation of immune cells, or whether it is related to an immune dysfunction. To investigate this problem, we evaluated serum levels of sIL-2R before and after administration of a highly lymphocytolitic chemotherapy (FEC: fluorouracil, epirubicin, cyclophosphamide) in a group of 6 patients with advanced breast cancer. SIL-2R were analyzed in relation to lymphocyte number. Absolute mean number of lymphocytes was significantly lower
Abstract by C. Archili; P. Lissoni; G. Cattaneo; F. Rovelli; F. Brivio; G. Tancini; S. Barni, The International Journal of Biological Markers (1990) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1177/172460089000500109