Species-wide whole genome sequencing reveals historical global spread and recent local persistence in Shigella flexneri
Thomas R. Connor; Clare R. Barker; Kate S. Baker; François‐Xavier Weill; Kaisar A. Talukder; Anthony M. Smith; Stephen Baker; Malika Gouali · 2015 · eLife
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Abstract
Shigella flexneri is the most common cause of bacterial dysentery in low-income countries. Despite this, S. flexneri remains largely unexplored from a genomic standpoint and is still described using a vocabulary based on serotyping reactions developed over half-a-century ago. Here we combine whole genome sequencing with geographical and temporal data to examine the natural history of the species. Our analysis subdivides S. flexneri into seven phylogenetic groups (PGs); each containing two-or-more serotypes and characterised by distinct virulence gene complement and geographic range. Within the
Abstract by Thomas R. Connor; Clare R. Barker; Kate S. Baker; François‐Xavier Weill; Kaisar A. Talukder; Anthony M. Smith; Stephen Baker; Malika Gouali, eLife (2015) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.7554/elife.07335