BMP9 attenuates microgravity-related disuse osteoporosis by modulating TGFβ and BMP signaling
Haoyang Zhao; Mengfan Yang; Yujiao Liu; Xiaolin Tu; Gaohai Shao · 2025 · npj Microgravity
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Disuse osteoporosis, caused by mechanical unloading, is linked to dysregulated TGFβ and BMP signaling. This study explores their roles and evaluates BMP9 as a potential therapy. A hindlimb unloading (HLU) mouse model was used to assess bone changes and signaling alterations. In vitro, a Rotary Cell Culture System (RCCS) with 3D printing simulated microgravity. BMP9 was overexpressed in bone marrow stromal cells (BMSCs) and osteocytes treated with TGFβ1. HLU mice showed reduced bone density, microstructural integrity, and dysregulated signaling (increased p-Smad2/3, decreased p-Smad1/5
Abstract by Haoyang Zhao; Mengfan Yang; Yujiao Liu; Xiaolin Tu; Gaohai Shao, npj Microgravity (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1038/s41526-025-00510-y