Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species
Jialin Fan; Yunpeng Xu · 2026 · Frontiers in Genetics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Dietary restriction (DR), defined as reduced caloric intake or selective limitation of specific nutrients without malnutrition, is one of the most robust interventions known to extend lifespan and healthspan across species. Studies from yeast to mammals demonstrate that DR elicits conserved genetic, transcriptional, and epigenetic programs that promote cellular maintenance and stress resistance. At the molecular level, DR engages evolutionarily conserved nutrient-sensing pathways, including insulin/IGF-1 signaling (IIS), the mechanistic target of rapamycin (mTOR), AMP-activated protein kinase
Abstract by Jialin Fan; Yunpeng Xu, Frontiers in Genetics (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fgene.2026.1771707