Impact of exposure to malaria and nutritional status on responses to the experimental malaria vaccine ChAd63 MVA ME-TRAP in 5-17 month-old children in Burkina Faso
Richard Morter; Alfred B. Tiono; Alfred B. Tiono; Issa Nébié; Oliver Hague; Alphonse Ouedraogo; Amidou Diarra; Nicola K. Viebig · 2022 · Frontiers in Immunology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
The finding, in one line
“However, it failed to demonstrate efficacy in a phase IIb trial in 5-17 month-old children in an area of high malaria transmission in Burkina Faso.”
Abstract
The experimental malaria vaccine ChAd63 MVA ME-TRAP previously showed protective efficacy against Plasmodium falciparum infection in Phase IIa sporozoite challenge studies in adults in the United Kingdom and in a Phase IIb field efficacy trial in Kenyan adults. However, it failed to demonstrate efficacy in a phase IIb trial in 5-17 month-old children in an area of high malaria transmission in Burkina Faso. This secondary analysis investigated whether exposure to malaria or nutritional status might be associated with reduced responses to vaccination in this cohort. Parasite blood smears and ant
Abstract by Richard Morter; Alfred B. Tiono; Alfred B. Tiono; Issa Nébié; Oliver Hague; Alphonse Ouedraogo; Amidou Diarra; Nicola K. Viebig, Frontiers in Immunology (2022) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fimmu.2022.1058227