Challenges in mimicking hypoxia: insights into HIF-regulated MiRNA expression induced by DMOG and CoCl2
Anna Barton; Maciej Jaśkiewicz; Anna Więch -Walów; Adrianna Moszyńska; Aleksandra Cabaj; Ben Wielockx; Liliana Schaefer; James F. Collawn · 2025 · Cell Communication and Signaling
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract The cellular and tissue response to acute hypoxia is mediated by a complex adaptive response initiated by hypoxia-inducible factors (HIF) 1 and 2. HIF proteins are key transcription factors that modulate gene expression to adapt cells to the low oxygen tension. Cellular studies of hypoxia have used the low oxygen model by using hypoxia chambers to monitor the gene expression changes, while others have utilized hypoxia mimetics in normoxic conditions. Here, we provide a comparison of the utility and limitations of two hypoxia mimetics by studying the changes in the miRNA and mRNA expre
Abstract by Anna Barton; Maciej Jaśkiewicz; Anna Więch -Walów; Adrianna Moszyńska; Aleksandra Cabaj; Ben Wielockx; Liliana Schaefer; James F. Collawn, Cell Communication and Signaling (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s12964-025-02459-7