When to Trust Epigenetic Clocks: Avoiding False Positives in Aging Interventions
Daniel S. Borrus; Raghav Sehgal; Judith Armstrong; Jessica Kasamoto; John T. González; Albert Higgins‐Chen · 2026 · Aging Cell
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
ABSTRACT Epigenetic clocks have emerged as potential biomarkers of aging due to their association with morbidity and mortality. They have recently gained traction as outcome measurements for anti‐aging interventions. However, as the number of new epigenetic clocks continues to grow, different clocks may not agree on the effect of an intervention. This raises the question of when researchers can trust epigenetic clock results. In this study, we find that when extending previously published single‐clock intervention studies to include additional clock models, no additional clocks reach statistic
Abstract by Daniel S. Borrus; Raghav Sehgal; Judith Armstrong; Jessica Kasamoto; John T. González; Albert Higgins‐Chen, Aging Cell (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1111/acel.70756