Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double‐blind, placebo‐controlled, multicenter trial: The MASTERS trial
R. Grace Walton; Cory M. Dungan; Douglas E. Long; S. Craig Tuggle; Kate Kosmac; Bailey D. Peck; Heather Bush; Alejandro Villasante‐Tezanos · 2019 · Aging Cell
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Progressive resistance exercise training (PRT) is the most effective known intervention for combating aging skeletal muscle atrophy. However, the hypertrophic response to PRT is variable, and this may be due to muscle inflammation susceptibility. Metformin reduces inflammation, so we hypothesized that metformin would augment the muscle response to PRT in healthy women and men aged 65 and older. In a randomized, double-blind trial, participants received 1,700 mg/day metformin (N = 46) or placebo (N = 48) throughout the study, and all subjects performed 14 weeks of supervised PRT. Although respo
Abstract by R. Grace Walton; Cory M. Dungan; Douglas E. Long; S. Craig Tuggle; Kate Kosmac; Bailey D. Peck; Heather Bush; Alejandro Villasante‐Tezanos, Aging Cell (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1111/acel.13039