Genome- and CD4+ T-cell methylome-wide association study of circulating trimethylamine-N-oxide in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN)
Stella Aslibekyan; Marguerite R. Irvin; Bertha A. Hidalgo; Rodney T. Perry; Elias J. Jeyarajah; Erwin Garcia; Irina Shalaurova; Paul N. Hopkins · 2017 · Journal of Nutrition & Intermediary Metabolism
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
The finding, in one line
“However, large-scale human studies have failed to replicate the observed genetic associations, and epigenetic factors such as DNA methylation have never been examined in relation to TMAO levels.”
Abstract
Background: Trimethylamine-N-oxide (TMAO), an atherogenic metabolite species, has emerged as a possible new risk factor for cardiovascular disease. Animal studies have shown that circulating TMAO levels are regulated by genetic and environmental factors. However, large-scale human studies have failed to replicate the observed genetic associations, and epigenetic factors such as DNA methylation have never been examined in relation to TMAO levels. Methods and results: We used data from the family-based Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) to investigate the heritable determi
Abstract by Stella Aslibekyan; Marguerite R. Irvin; Bertha A. Hidalgo; Rodney T. Perry; Elias J. Jeyarajah; Erwin Garcia; Irina Shalaurova; Paul N. Hopkins, Journal of Nutrition & Intermediary Metabolism (2017) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1016/j.jnim.2017.03.002