Altitude hypoxia and hypoxemia: pathogenesis and management
Chunmei Cai; Guohua Ni; Lei Chen; Cheng Deng; Shengjun Chai; Rui Wang; Rong Zhang; Fengming Luo · 2026 · Signal Transduction and Targeted Therapy
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
At high altitudes, which typically exceed 2500 m, approximately 80 million people reside permanently, with over a million visitors annually. The primary effect of high altitude is hypobaric hypoxia, which leads to decreased oxygen availability and a cascade of physiological responses. However, inadequate or excessive responses can lead to malacclimatization, resulting in hypoxemia and various high-altitude illnesses, including acute mountain sickness (AMS), high-altitude cerebral edema (HACE), high-altitude pulmonary edema (HAPE), chronic mountain sickness (CMS), and high-altitude pulmonary hy
Abstract by Chunmei Cai; Guohua Ni; Lei Chen; Cheng Deng; Shengjun Chai; Rui Wang; Rong Zhang; Fengming Luo, Signal Transduction and Targeted Therapy (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41392-025-02531-1