The Mechanism of Gefitinib Resistance Induced by Hepatocyte Growth Factor in Sensitive Non-small Cell Lung Cancer Cells in Vitro
Xianglan XUAN; Changshan AN; Caicun ZHOU · 2013 · Chinese Journal of Lung Cancer
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Abstract
Background and objective Previous studies have reported that Met might be related to gefitinib resistance in non-small cell lung cancer (NSCLC). The present study aims to explore the mechanism of hepatocyte growth factor (HGF)-induced gefitinib resistance in different gene types of sensitive NSCLC in vitro. Methods The PC-9 and H292 cell lines were chosen and induced by HGF. The cell survival was measured using MTT assay, the cell cycle distribution was measured using PI assay, and cell apoptosis with an Annexin V-PE assay, respectively. The c-Met and p-Met protein expression was determined vi
Abstract by Xianglan XUAN; Changshan AN; Caicun ZHOU, Chinese Journal of Lung Cancer (2013) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3779/j.issn.1009-3419.2013.01.01