Human essential hypertension: no significant association of polygenic risk scores with antihypertensive drug responses
Heini Sánez Tähtisalo; Sanni Ruotsalainen; Nina Mars; Kimmo Porthan; Lasse Oikarinen; Juha Virolainen; F Fyhrquist; Samuli Ripatti · 2020 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Polygenic risk scores (PRSs) for essential hypertension, calculated from > 900 genomic loci, were recently found to explain a significant fraction of hypertension heritability and complications. To investigate whether variation of hypertension PRS also captures variation of antihypertensive drug responsiveness, we calculated two different PRSs for both systolic and diastolic blood pressure: one based on the top 793 independent hypertension-associated single nucleotide polymorphisms and another based on over 1 million genome-wide variants. Using our pharmacogenomic GENRES study comprising four
Abstract by Heini Sánez Tähtisalo; Sanni Ruotsalainen; Nina Mars; Kimmo Porthan; Lasse Oikarinen; Juha Virolainen; F Fyhrquist; Samuli Ripatti, Scientific Reports (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41598-020-68878-3