Distinct cell types along thick ascending limb express pathways for monovalent and divalent cation transport
Hasan Demirci; Jessica Paola Bahena-López; Смородченко Алина Тихоновна; Xiao‐Tong Su; Jonathan W. Nelson; Chao‐Ling Yang; Joshua N. Curry; Xin‐Peng Duan · 2025 · JCI Insight
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Kidney thick ascending limb cells reabsorb sodium, potassium, calcium, and magnesium and contribute to urinary concentration. These cells are typically viewed as of a single type that recycles potassium across the apical membrane and generates a lumen-positive transepithelial voltage driving calcium and magnesium reabsorption, although variability in potassium channel expression has been reported. Additionally, recent transcriptomic analyses suggest that different cell types exist along this segment, but classifications have varied and have not led to a new consensus model. We used immunolocal
Abstract by Hasan Demirci; Jessica Paola Bahena-López; Смородченко Алина Тихоновна; Xiao‐Tong Su; Jonathan W. Nelson; Chao‐Ling Yang; Joshua N. Curry; Xin‐Peng Duan, JCI Insight (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1172/jci.insight.190992