Association of dengue virus‐specific polyfunctional T‐cell responses with clinical disease severity in acute dengue infection
Dulharie T. Wijeratne; Samitha Fernando; Laksiri Gomes; Chandima Jeewandara; Geethal Jayarathna; Yashoda Perera; Samurdhi Wickramanayake; Ananda Wijewickrama · 2019 · Immunity, Inflammation and Disease
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Abstract
Abstract Introduction Although the role of dengue virus (DENV)‐specific T cells in the pathogenesis of acute dengue infection is emerging, the functionality of virus‐specific T cells associated with milder clinical disease has not been well studied. We sought to investigate how the functionality of DENV–NS3 and DENV–NS5 protein‐specific T cells differ in patients with dengue fever (DF) and dengue hemorrhagic fever (DHF). Methods Using intracellular cytokine assays, we assessed the production of interferon γ (IFNγ), tumor necrosis factor‐α (TNF‐α), macrophage inflammatory protein‐1β (MIP‐1β), a
Abstract by Dulharie T. Wijeratne; Samitha Fernando; Laksiri Gomes; Chandima Jeewandara; Geethal Jayarathna; Yashoda Perera; Samurdhi Wickramanayake; Ananda Wijewickrama, Immunity, Inflammation and Disease (2019) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1002/iid3.271