Oncolytic Viruses in Cancer Immunotherapy: From Molecular Engineering to Clinical Translation
Mohammad Fayyad‐Kazan; Sarah Ayad Al-Tameemi; Allal Ouhtit · 2026 · Cells
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Cancer immunotherapy has transformed modern oncology, yet durable responses remain limited for many patients due to immune exclusion, adaptive resistance, and tumor heterogeneity. Oncolytic viruses (OVs) have emerged as a novel class of immunotherapeutics that unify direct tumor cytolysis with stimulation of antitumor immunity. By inducing immunogenic cell death (ICD) and releasing tumor-associated antigens (TAAs), OVs remodel the tumor microenvironment (TME) into an inflamed and immune-permissive niche capable of enabling systemic immune activation. Rapid advances in viral engineering have st
Abstract by Mohammad Fayyad‐Kazan; Sarah Ayad Al-Tameemi; Allal Ouhtit, Cells (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/cells15050393