Smoking, alcohol consumption, and cancer: A mendelian randomisation study in UK Biobank and international genetic consortia participants
Susanna C. Larsson; Paul Carter; Siddhartha Kar; Mathew Vithayathil; Amy M. Mason; Karl Michaëlsson; Stephen Burgess · 2020 · PLoS Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Smoking is a well-established cause of lung cancer and there is strong evidence that smoking also increases the risk of several other cancers. Alcohol consumption has been inconsistently associated with cancer risk in observational studies. This mendelian randomisation (MR) study sought to investigate associations in support of a causal relationship between smoking and alcohol consumption and 19 site-specific cancers. METHODS AND FINDINGS: We used summary-level data for genetic variants associated with smoking initiation (ever smoked regularly) and alcohol consumption, and the corr
Abstract by Susanna C. Larsson; Paul Carter; Siddhartha Kar; Mathew Vithayathil; Amy M. Mason; Karl Michaëlsson; Stephen Burgess, PLoS Medicine (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pmed.1003178