Inhibition of the NOD-Like Receptor Protein 3 Inflammasome Is Protective in Juvenile Influenza A Virus Infection
Bria M. Coates; Kelly L. Staricha; Nandini Ravindran; Clarissa M. Koch; Yuan Cheng; Jennifer Davis; Dale K. Shumaker; Karen M. Ridge · 2017 · Frontiers in Immunology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Influenza A virus (IAV) is a significant cause of life-threatening lower respiratory tract infections in children. Antiviral therapy is the mainstay of treatment, but its effectiveness in this age group has been questioned. In addition, damage inflicted on the lungs by the immune response to the virus may be as important to the development of severe lung injury during IAV infection as the cytotoxic effects of the virus itself. A crucial step in the immune response to IAV is activation of the NOD-like receptor protein 3 (NLRP3) inflammasome and the subsequent secretion of the inflammatory cytok
Abstract by Bria M. Coates; Kelly L. Staricha; Nandini Ravindran; Clarissa M. Koch; Yuan Cheng; Jennifer Davis; Dale K. Shumaker; Karen M. Ridge, Frontiers in Immunology (2017) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fimmu.2017.00782