Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice
M. Oksman; H. Iivonen; E. Hogyes; Z. Amtul; B. Penke; I. Leenders; L. Broersen; D. Lütjohann · 2006 · Neurobiology of Disease
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The present study assessed the influence of dietary lipids on accumulation of amyloid beta-peptide (Aβ) in the brain. Seven experimental diets with varying n-6/n-3-ratio, saturated and polyunsaturated fatty acid and cholesterol contents were fed to transgenic APPswe/PS1dE9 mice for 3–4 months beginning at a young adult age (6 months). Hippocampal Aβ levels were determined with ELISA and plaque load by using immunocytochemistry. A typical Western diet with 40% saturated fatty acids and 1% of cholesterol increased, while diets supplemented with docosahexaenoic acid (DHA) decreased Aβ levels comp
Abstract by M. Oksman; H. Iivonen; E. Hogyes; Z. Amtul; B. Penke; I. Leenders; L. Broersen; D. Lütjohann, Neurobiology of Disease (2006) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1016/j.nbd.2006.04.013