Effects of simvastatin on white matter integrity in healthy middle‐aged adults
Nicholas M. Vogt; Jack F. V. Hunt; Yue Ma; Carol A. Van Hulle; Nagesh Adluru; Richard J. Chappell; Karen K. Lazar; Laura E Jacobson · 2021 · Annals of Clinical and Translational Neurology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background The brain is the most cholesterol‐rich organ and myelin contains 70% of total brain cholesterol. Statins are potent cholesterol‐lowing medications used by millions of adults for prevention of vascular disease, yet the effect of statins on cholesterol‐rich brain white matter (WM) is largely unknown. Methods We used longitudinal neuroimaging data acquired from 73 healthy, cognitively unimpaired, statin‐naïve, middle‐aged adults during an 18‐month randomized controlled trial of simvastatin 40 mg daily (n = 35) or matching placebo (n = 38). ANCOVA models (covariates: age, sex,
Abstract by Nicholas M. Vogt; Jack F. V. Hunt; Yue Ma; Carol A. Van Hulle; Nagesh Adluru; Richard J. Chappell; Karen K. Lazar; Laura E Jacobson, Annals of Clinical and Translational Neurology (2021) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1002/acn3.51421