A specific microRNA profile as predictive biomarker for systemic treatment in patients with metastatic colorectal cancer
Dennis Poel; Elske C. Gootjes; Lotte Bakkerus; Wim Trypsteen; Henk Dekker; Hans J. van der Vliet; Nicole C.T. van Grieken; Cornelis Verhoef · 2020 · Cancer Medicine
WASTE classifies this as Replication Failure · AI classification, approximate
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Abstract
BACKGROUND: Palliative systemic therapy is currently standard of care for patients with extensive metastatic colorectal cancer (mCRC). A biomarker predicting chemotherapy benefit which prevents toxicity from ineffective treatment is urgently needed. Therefore, a previously developed tissue-derived microRNA profile to predict clinical benefit from chemotherapy was evaluated in tissue biopsies and serum from patients with mCRC. METHODS: Samples were prospectively collected from patients (N = 132) who were treated with capecitabine or 5-FU/LV with oxaliplatin ± bevacizumab. Response evaluation wa
Abstract by Dennis Poel; Elske C. Gootjes; Lotte Bakkerus; Wim Trypsteen; Henk Dekker; Hans J. van der Vliet; Nicole C.T. van Grieken; Cornelis Verhoef, Cancer Medicine (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1002/cam4.3371