Multi-metric evaluations of acute psychedelic effects on fMRI brain entropy
Drummond E-Wen McCulloch; Anders S. Olsen; Brice Ozenne; K O Larsen; Dea Siggaard Stenbæk; Sophia Armand; Martin Korsbak Madsen; Gitte M. Knudsen · 2026 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
A prominent theory of psychedelics is that they increase brain entropy. Thirteen studies have evaluated psychedelic effects on fMRI brain entropy, each applying a distinct measure. Here we evaluated these metrics in an independent 28-participant healthy cohort with 121 pre- and post-psilocybin fMRI scans. We assessed relations between brain entropy and objective and subjective psychedelic drug effects using linear mixed-effects models. All metrics were evaluated using two parcellation strategies and 7 denoising pipelines. We observed consistent significant positive associations for Shannon ent
Abstract by Drummond E-Wen McCulloch; Anders S. Olsen; Brice Ozenne; K O Larsen; Dea Siggaard Stenbæk; Sophia Armand; Martin Korsbak Madsen; Gitte M. Knudsen, Nature Communications (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41467-026-74215-5