Spatial transcriptomics reveals influence of microenvironment on intrinsic fates in melanoma therapy resistance
Ryan H. Boe; Catherine G. Triandafillou; Rossana Lazcano; Jennifer A. Wargo; Arjun Raj · 2026 · Genome biology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Resistance to cancer therapy is driven by both cell-intrinsic and microenvironmental factors. We use spatial transcriptomics and single-cell RNA sequencing to uncover distinct resistance programs in melanoma cells shaped by intrinsic cellular states and the tumor microenvironment. Consensus non-negative matrix factorization reveals shared intrinsic resistance programs across cell lines. In patient samples, these resistance programs coexist within individual tumors and associate with diverse immune signatures. Single-cell resolution spatial transcriptomics in xenograft models reveals b
Abstract by Ryan H. Boe; Catherine G. Triandafillou; Rossana Lazcano; Jennifer A. Wargo; Arjun Raj, Genome biology (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s13059-026-04112-z