Oestradiol and reproductive outcomes in ART: when too much of a good thing hurts
Mathilde Bourdon; Chloé Maignien; Marion Ouazana; Fleur Kefelian; Louis Marcellin; Catherine Patrat; Khaled Pocate-Cheriet; Charles Chapron · 2025 · Reproductive BioMedicine Online
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Oestradiol plays a crucial role in reproduction, particularly in assisted reproductive technology (ART), where it can reach supraphysiological concentrations. These fluctuations occur during ovarian stimulation in fresh embryo transfer cycles and during endometrial preparation for frozen embryo transfer, potentially impacting implantation and perinatal outcomes. Oestradiol influences endometrial proliferation, receptivity, implantation and placentation, with the sensitivity of the endometrium to systemic oestrogen emerging as a key determinant of reproductive success. In fresh embryo transfer
Abstract by Mathilde Bourdon; Chloé Maignien; Marion Ouazana; Fleur Kefelian; Louis Marcellin; Catherine Patrat; Khaled Pocate-Cheriet; Charles Chapron, Reproductive BioMedicine Online (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.rbmo.2025.105131