Nrf2-Activating Natural Compounds in Neurodegenerative Diseases: Targeting Oxidative Stress and Protein Aggregation
Lucia Chico; Erika Schirinzi; Linda Balestrini; Maico Polzella; Gabriele Siciliano · 2026 · International Journal of Molecular Sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Neurodegenerative diseases (NDs) are among the leading causes of disability and mortality worldwide and are characterized by multifactorial pathogenesis involving interconnected mechanisms, such as oxidative stress, protein misfolding and aggregation, neuroinflammation, and mitochondrial dysfunction. Dysregulation of transcription factors, governing cellular defense responses, particularly nuclear factor erythroid 2-related factor 2 (Nrf2), a key regulator of antioxidant and proteostatic pathways, plays a critical role in neurodegenerative processes. Currently, available pharmacological treatm
Abstract by Lucia Chico; Erika Schirinzi; Linda Balestrini; Maico Polzella; Gabriele Siciliano, International Journal of Molecular Sciences (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/ijms27031592